| Fountain Valley 48, Vanguard 39 | Dec. 1 | Details |
| Vanguard 45, Cripple Creek-Victor 35 | Dec. 3 | Details |
| Front Range Christian 50, Vanguard 34 | Dec. 9 | Details |
| Vanguard 55, Cripple Creek-Victor 39 | Dec. 10 | Details |
| Vanguard 51, Miami-Yoder 36 () | Jan. 6 | Details |
| Byers 62, Vanguard 38 | Jan. 7 | Details |
| Calhan 70, Vanguard 36 () | Jan. 13 | Details |
| Evangelical Christian Academy 60, Vanguard 51 () | Jan. 14 | Details |
| Limon 70, Vanguard 42 () | Jan. 20 | Details |
| Vanguard 47, Fountain Valley 39 () | Jan. 21 | Details |
| Vanguard 58, Ellicott 46 | Jan. 27 | Details |
| Kiowa vs. Vanguard at Kiowa () | Jan. 28 @ 4 p.m. | Map |
| Elbert 45, Vanguard 31 | Jan. 31 | Details |
| Peyton 73, Vanguard 41 () | Feb. 4 | Details |
| Vanguard 49, Colorado Springs School 47 () | Feb. 6 | Details |
| Miami-Yoder vs. Vanguard at Miami-Yoder High School () | Feb. 10 @ 7:30 p.m. | Map |
| Calhan 61, Vanguard 52 () | Feb. 11 | Details |
| Evangelical Christian Academy vs. Vanguard at Evangelical Christian Academy () | Feb. 17 @ 8:30 p.m. | Map |
| Peyton 62, Vanguard 35 () | Feb. 22 | Details |
| Colorado Springs School 50, Vanguard 43 | Feb. 23 | Details |
